HiSeq X

Choose the Right Sequencer

For tips about how to choose the best sequencer and transform your lab, Use this checklist to guide your decision making as you evaluate sequencers for your lab.

High-Throughput Library Prep Automation

Save time and expense by taking advantage of Illumina qualified library prep automation methods.

High Throughput Flipbook

Investigate a number of High-Throughput applications that can run on the HiSeq Series.

The HiSeq X Ten System is the world’s first to break the $1000 genome barrier for human whole-genome sequencing (WGS). The system consists of a set of 10 HiSeq X ultra-high-throughput instruments that deliver over 18,000 human genomes per year. Each HiSeq X System can sequence a human genome at 30x coverage or greater for significantly less than $1000 in consumables.*

The HiSeq X Ten System was purpose-built for population-scale WGS. The 10 instruments of a HiSeq X Ten System generate a staggering level of throughput for processing tens of thousands of samples. The HiSeq X Ten empowers scientists, institutions, and nations to create a comprehensive catalog of human and species variation, forge population-based references, drive far-reaching discoveries, and advance the study of cancer and complex diseases at a record pace.

HiSeq X Sequencing System also enables cost-effective WGS for non-human species with unrivaled throughput. The HiSeq X System delivers high coverage in a variety of areas, including agriculture and model organism research in the pharmaceutical industry. By providing ultra-high throughput and a low price point per genome, the HiSeq X System provides customers with an opportunity to reshape the economics and scale of WGS beyond the human species.

The technological advancements provided by the HiSeq X Series change the economics of variant detection, driving price parity between whole-exome and whole-genome sequencing for variant detection in exonic regions. WGS also provides greater coverage uniformity and higher sensitivity at lower depths of coverage compared to exome sequencing.1

Opening an unconstrained view of the entire genome, not just the 2% represented by the exome, lets researchers discover and identify important disease variants both inside and outside coding regions, and detect structural variants and genomic rearrangements.

1. Meynert AM, Ansari M, FitzPatrick DR, Taylor MS. Variant detection sensitivity and biases in whole genome and exome sequencing. BMC Bioinformatics. 2014;15:247

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